90Plus
The new 90Plus particle sizer incorporates all you need for fast, routine, sub micron measurements. Based on the principles of Dynamic Light Scattering (DLS), most measurements only take a minute or two. The built-in PC computer has ample power for the Windows™-based software. Choose from the standard 35 mW laser for strong scatterers, or the avalanche photo diode for weak scatterers. And, at the time of manufacture, or as a future upgrade, add the BI-Zeta option for zeta potential measurements.
Two Scattering Angles:
Most measurements will be made at the 90° scattering angle, however, the user may select the 15° detection angle
where measurements are more sensitive to larger particles
NanoDLS
The NanoDLS is the gateway to absolute nanoparticle sizing including proteins and their aggregates (oligomers), polymers, dendrimers, micelles, and other colloidal materials. Either online (ASEC or GPC/SEC), or in batch-mode, it is an excellent tool for determination of hydrodynamic radii from 0.5 nm to a few microns.
Based on the principles of dynamic light scattering, the NanoDLS uses an automatic, variablepower laser at 638 nm, maximum 35 mW power, a patented* optical cell design, a single-mode fiber, a self-protecting avalanche photodiode and a 25ns/522-channel digital autocorrelator. Due to the patented* cell, the NanoDLS can measure samples from extremely low to high concentrations. Such a design allows for small volumes and a vertical flow pattern, minimizing the effects of bubbles.
For globular proteins and other rare samples, sizes are often small and concentrations low. Because of its unique and patented cell design, the NanoDLS makes obtaining reliable data from such samples easy. In addition aggregate (oligomer) formation is readily probed because light scattering is supremely sensitive to small amounts of larger species.
The NanoDLS is a superb addition to existing and new chromatography systems for the characterization of proteins and polymers since the instrument enables particle sizing without column or instrument calibration. The high sensitivity and small-volume cell allows for low sample concentrations and small injection volumes. These features lead to accurate, absolute data from minute amounts of sample
BioDLS
Particle sizing, by dynamic light scattering, is an invaluable technique for formulation characterization and aggregation studies. It works with unmodified, undiluted samples. It offers exquisite sensitivity to enable detection of even the initiation of aggregation, information that is invaluable to the pharmaceutical scientist concerned about loss of activity or immunogenicity in pharmaceutical preparations, or to the pharmacologist screening for potentially therapeutic inhibitors of aggregation. Until recently, however, the power of this technology has not been capable of meeting industrial throughput requirements.
Now Brookhaven Instruments, the company that has pioneered fundamental innovation in light scattering for thirty years, is proud to announce the release of the BioDLS, an instrument that combines the power of dynamic light scattering with modern automatic liquid handling to yield unsurpassed convenience and accuracy in formulation characterization and aggregation assays.
The BioDLS allows automatic particle sizing using industry�standard well plates. The precision controlled sample transfer mechanism allows the user to select any arbitrary well to initiate the experiment, as little as 2 µL sample volume is required for a measurement, and allows recovery of the transferred sample. Samples can be stored in up to two 384-well plates in an independently temperature-controlled compartment, and up to 768 samples can be transferred automatically to the flow cell without user intervention. The measuring cell has independent temperature control, allowing thermal studies related to stability and aggregation on individual samples. These features, coupled with the high-throughput fluid handling, allow the sensitivity, precision, and accuracy required for biotechnology and pharmaceutical research on proteins, peptides, viruses and antibodies.
FOQELS
At last, a simple, practical approach to automatic particle size analysis of concentrated suspensions. Brookhaven Instruments brings together the fiber-optic (FO) detection and quasi-elastic light-scattering (QELS) technologies to create the innovative FOQELS particle size analyzer. The Brookhaven FOQELS particle size analyzer allows measurements to be made over a much greater range of concentrations than than standard Dynamic Light Scattering (DLS) instruments.
The unique, state-of-the-art, optical microfiber probe (US Pat. No. 5,155,549) provides the key technology for a compact and inexpensive instrument to measure in suspensions concentrated up to 40% by weight.
Our new high-temperature sample cell holder provides controlled temperatures from ambient up to 160° C. This device uses a space-age insulation material and is ideal for applications such as high-temperature oils.
BI-DCP
The Brookhaven BI-DCP is a digitally controlled, high resolution, particle size distribution analyzer. It yields high resolution results in the size range from 0.01 to 30 microns with typical analysis times ranging from 5 to 30 minutes. The DCP software provides easy instrument control, data analysis, and database management. The software is menu-driven and permits a variety of report formats.
Brookhaven Instruments is renowned for light scattering instruments dedicated to sub-micron particle sizing and polymer characterization. Having identified the need to produce high resolution in the 1 micron size range, Brookhaven has produced an instrument with resolution unmatched by any other technique in this range. Sedimention is intrinsically a fractionation technique and the BI-DCP provides a means to separate the components of mixtures and also characterize a wide variety of distributions.
BI-XDC
By providing both centrifugal and gravitational sedimentation in one instrument the BI-XDC brings these well established methods of particle sizing up to date for today's fine particle technology. With an X-ray technology to give error free measurements, fast and accurate size distributions across the "one-micron" transition region are easily obtained. Now, with a single instrument you can get true high resolution, accurate, particle size distributions from 10 nanometers right up to 100 microns. Brookhaven's advanced scanning detector technology and wide disc speed range lets you optimize analysis times and broaden the range of samples you can analyze.
With the Brookhaven Bl-XDC there are no optical corrections and no optical properties to worry about, just a simple mass sensitive response based on X-ray absorption.
